Mitragynine and 7-hydroxymitragynine are the two primary active ingredients in Kratom. These compounds are indole alkaloids native to the Southeast Asia plant named Mitragyna speciosa(Kratom) and act on the brain’s opioid receptors. Traditionally, they were used for stimulant and analgesic purposes. Mitragynine is more abundant and extremely popular among scientists for its role in Kratom’s effects.
In kratom testing and research, it was found that 7-hydroxymitragynine, present in lesser quantities, is vital to Kratom’s pain-relieving, mood-relaxing, and stress-boosting properties. To enhance its effect, it comes in portable edible form, which is hydroxie kratom chewable tablets. In this blog, we will understand 7-hydroxymitragynine in detail.
What is 7-hydroxymitragynine?
7-hydroxymitragynine is also known as 7-OH mitragynine, 7-hydroxymitragynine is an active metabolite of mitragynine. Similar to morphine, 7-Oh is a substance that enhances mitragynine’s pain-relieving effects. Like morphine, it strongly activates mu-opioid receptors. Some studies have shown that 7-hydroxymitragynine binds these receptors with even greater force than morphine. Other than opioid receptors, it also affects dopamine, serotonin, and adrenergic receptors.
After consuming kratom, much of the 7OH present in the body is not from the plant but is produced metabolically when the liver processes mitragynine. In this transformation, the pharmacological activity of this compound gets increased and hence, gives kratom its distinctive effects of pain relief, mood enhancement, and sedation.
According to PubMed Central, “Kratom contains a number of indole alkaloids that are believed to be the primary contributors to its psychoactive effects. Chief among these is mitragynine, which typically constitutes 1–2% of the dry leaf mass and up to approximately two-thirds of the total alkaloid content. This compound is joined by 7-hydroxymitragynine (7-OH) in much lower concentrations, typically less than 0.05% of the dried leaf mass.”
Effects of 7-Hydroxymitragynine
Due to its potent opioid- like properties, several pharmacological actions are included in 7-Hydroxymitragynine’s effect. These effects are explained below:
Pain-Relieving: The analgesic effects of 7-hydroxymitragynine are effective for relieving pain by acting on the mu-opioid receptors. It can be considered a natural alternative to painkillers as it is highly effective in managing chronic pain.
Withdrawal Effects: The compound has a lower risk of developing addiction as compared to opioids. The kratom leaves and their extracts tend to have tender withdrawal symptoms. However, it can be addictive and show tolerance, and withdrawal symptoms when 7-Oh is isolated as a concentrated chronic.
Euphoric and sedating: 7-Hydroxymitragynine can produce intense pleasure and exciting effects in whole kratom extracts at recreational levels.
Possible Medical Usage: It can be used in helping people wean off opioids. It can reduce opioid tolerance and alleviate withdrawal symptoms.
7-Hydroxy Gummies & Tablets
The Hydroxide Kratom tablets & gummies are edibles crafted to deliver consistent dosing and powerful effects, tailored to your unique needs.
- 7-Hydroxy gummies are infused with potent 7-hydroxy extract, providing a fast-acting and elevating experience for the individual seeking precise, consistent, and stronger effects.
- 7-Hydroxy Tablets are perfectly convenient and provide discreet, reliable doses of 7-OH extract for consistent effect. These are ideal for users who prefer pre-measured dosage.
Key Difference between 7-Hydroxy & THC
7-Hydroxy (Kratom) and THC, both components extracted naturally. They are often compared due to the mood-altering and pain-relieving effects. Even though they have similarities but both compounds have different origins, procedures, and effects on your body. Some of these effects are explained below:
Kratom or 7-Hydroxy
- Kratom, also known as 7-Hydroxy, is derived from the leaves of the Mitragyna Speciosa plant.
- 7-OH contains mitragynine and 7-hydroxymitragynine and primarily affects the brain’s opioid receptors.
- It does not induce any psychoactive effect until consumed in a very large amount.
- Because of its interaction with the brain’s opioid receptors, it can be used to manage pain, anxiety, and opioid withdrawal symptoms.
THC or tetrahydrocannabinol
- THC is a primary psychoactive compound found in the cannabis plant.
- It affects the parts which are responsible for mood, memory, and sensory perception by working through the body’s endocannabinoid system.
- This compound induces psychoactive effects such as the sensation of being “high”
- It is effective in stimulating appetite, reducing nausea, and managing conditions like PTSD, anxiety, and chronic pain.
The key difference between Kratom and THC is that Kratom primarily works on opioid receptors, which offer stimulant or sedative effects. Whereas, THC produces psychoactive effects by interacting with the endocannabinoid system.
Despite their different effects, they also possess some similarities. Both of these are highly efficient in their edible forms. Just like 7-OH is induced in tablet form, THC is also highly popular when infused with different flavors to form chewable THC delta 9 gummies.
These edibles are generally designed to provide precision and consistency for every type of user.
Conclusion
The concentration of 7-hydroxymitragynine may be less in Kratom, but the impact is major. Being a dominant analgesic and mood enhancer, 7-OH offers potential benefits for those who seek a natural alternative to opioids. Even if it is beneficial, it should be taken with caution by examining its potency and potential risks.
Note: This article is for informational purposes only. It should not be considered as medical advice. Always take advice from a healthcare professional before using kratom or any other CBD substance.
Disclaimer: The information provided in this article is based on available research and should not be considered a substitute for professional medical advice. Kratom use should be guided by individual tolerance and needs, and it’s essential to follow proper guidelines to ensure safe and effective use.